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Hamilton first noted that androgens (testosterone, dihydrotestosterone) are necessary for the development of MPHL. The amount of androgens present does not need to be greater than normal for MPHL to occur. If androgens are present in normal amounts and the gene for hair loss is present, male pattern hair loss will occur. Axillary (under arm) and pubic hair are dependent on testosterone for growth. Beard growth and male pattern hair loss loss are weimaraners dependent on dihydrotestosterone (DHT). Testosterone is converted to DHT by the enzyme, 5a -reductase. Finasteride (Propecia) acts by blocking this enzyme and decreasing the amount of DHT. Receptors exist on cells that bind androgens. These receptors have the greatest affinity for and DHT followed by testosterone, estrogen, and progesterone. After binding to the receptor, hair DHT goes into the cell and interacts with the nucleus of the cell altering the production of protein by the DNA in the nucleus of the cell. Ultimately growth of the hair loss follicle ceases.
In the United States weimaraners it and is estimated that 21 million women are affected by FPHL. The incidence in women has been reported to be hair as low as eight percent and loss as high as 87 percent. It does appear to be as common in women as in men. The hair loss in women becomes particularly notable in menopause.Androgens are responsible for hair loss in women by the same mechanisms they cause hair loss in men. Women do produce small amounts of androgens by way of the ovaries and adrenal glands. Also prehormones are produced by the ovaries that are converted to androgens outside of the ovaries or adrenal glands. Women weimaraners rarely experience total loss of hair in an area if the loss is and due to FPHL. If they do they hair should be evaluated for an underlying pathological (disease) condition. In women, the process loss of miniaturization weimaraners of the hair follicle is more random with some hair being unaffected. Normal thick hairs are mixed with finer, smaller diameter hairs. The end result is a visual decrease in density and of hair rather hair than total loss of hair. The hair growth loss cycle is affected as in men. The growth phase (anagen) is shortened resulting in shorter hairs and the resting phase (telogen) is increased resulting in fewer hairs.
Come here to find hair loss treatments. A University developed treatment to help reverse hair loss.
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