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The hair growth cycle (see "The Normal Hair Growth Cycle") is thyroig affected in that the percentage of hairs in the growth phase (anagen) and the duration of the growth phase diminish resulting in shorter hair hairs. loss More hairs are in the resting state (telogen) and these hairs are much more subject to loss with the daily trauma of combing and washing. The hair shafts in MPHL become progressively miniaturized, smaller in diameter and length, with time. In men with MPHL all the hairs in an affected area may eventually (but not necessarily) become involved in the process and may with time cover the region with fine (vellus) hair. Pigment (color) thyroig and hair production is also terminated with miniaturization so the fine hair becomes lighter in color. The lighter loss color, miniaturized hairs cause the area to first appear thin. Involved areas in men can completely lose all follicles over time. MPHL is an inherited condition and the gene can be inherited from either the mother or father’s side. There is a common myth that inheritance is only thyroig and hair from the mother’s side. This is not true.
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Hamilton first noted that androgens (testosterone, dihydrotestosterone) are necessary for the development of MPHL. The thyroig and hair amount of androgens present does not need to be greater loss than normal for MPHL to occur. If androgens are present in normal amounts and the gene for hair loss is present, male pattern hair thyroig loss will occur. Axillary (under arm) and pubic hair are dependent on testosterone hair for growth. Beard growth and male pattern hair loss are dependent loss on dihydrotestosterone (DHT). Testosterone is converted to DHT by the enzyme, 5a -reductase. Finasteride (Propecia) acts by blocking this enzyme and decreasing thyroig the amount of DHT. hair Receptors loss exist on cells that bind thyroig androgens. These receptors have the greatest affinity for DHT followed by testosterone, hair estrogen, and progesterone. After binding to the receptor, DHT goes into the cell and loss interacts with the nucleus of the cell altering the production of protein by the DNA in the nucleus of the cell. Ultimately growth of the hair follicle ceases.
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