methotrexate and hair loss
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Hamilton first noted that androgens (testosterone, dihydrotestosterone) are necessary for the development of MPHL. The amount of androgens present does not need to methotrexate be greater than normal for MPHL to occur. and and hair If androgens are present in normal amounts and the gene for hair loss is present, male pattern hair loss will occur. Axillary (under arm) and pubic hair are dependent on testosterone for growth. Beard growth and male pattern hair loss are dependent on dihydrotestosterone (DHT). Testosterone is converted to DHT by the enzyme, 5a -reductase. Finasteride loss (Propecia) acts by blocking this enzyme and decreasing the amount methotrexate of DHT. Receptors exist on cells that bind androgens. These receptors have the greatest affinity for DHT followed by testosterone, estrogen, and progesterone. After binding to the receptor, DHT goes into the cell and interacts with the nucleus of the cell altering the production of protein by the DNA in the nucleus of the cell. Ultimately growth of the hair follicle and ceases.
THE NORMAL HAIR GROWTH CYCLEIt is important to understand the normal hair growth hair cycle to understand loss why hair loss methotrexate occurs. and The hair follicle is an anatomical structure which evolved to produce and extrude (push out) a hair shaft. Hair is made up of proteins called keratins. Human hair grows in a continuous cyclic hair pattern of growth and rest known as the "hair growth cycle". Three phases of the cycle exist: Anagen= growth phase; Catagen=degradation phase; Telogen= resting phase. Periods of growth (anagen) between two and eight years are followed by a brief period, loss two to four weeks, methotrexate in which the follicle is almost totally degraded (catagen). The resting phase (telogen) then begins and lasts two to four months. Shedding of the hair occurs only after the next growth cycle (anagen) begins and a and new hair shaft begins hair to emerge. On average 50-100 telogen hairs are shed every day. loss This is normal hair loss and accounts for the hair loss seen every methotrexate day in the shower and with hair combing. These hairs will and regrow. Not more than 10 percent of the follicles hair are in the resting phase (telogen) at any time. A variety of factors can affect the hair growth cycle and cause temporary or permanent hair loss (alopecia) including medication, radiation, chemotherapy, exposure to chemicals, loss hormonal and nutritional factors, thyroid disease, generalized or local skin disease, and stress.
In summary, male pattern hair loss (Androgenetic Alopecia) is an inherited condition manifested when androgens are present in normal amounts. The gene can be inherited from the mother or father’s side. The onset, rate, and severity of hair loss are unpredictable. methotrexate The severity increases with age and if the condition is present it will be progressive and relentless.FEMALE PATTERN HAIR LOSS and (Androgenetic Alopecia)Female pattern hair loss (FPHL) differs from male pattern hair loss (MPHL) in the following ways. It is more likely to be noticed later than hair in men, in the late twenties through early forties. It is likely to be seen at times of hormonal change, i.e., use of birth control pills, after childbirth, around the time of menopause, and after menopause. Recession at the temples is less likely loss than in men and women methotrexate tend to maintain the position of their hairlines. and Like in men, the entire top of the scalp is the area of risk. In women there is generally a diffuse thinning throughout the area as opposed to thinning in the crown of men. Ludwig has classified hair loss in women into three classes. hair (See Ludwig Classification) The vast majority of women loss affected fall into the Ludwig I class.
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methotrexate and hair loss
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