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Hamilton first noted that androgens (testosterone, dihydrotestosterone) are necessary for the development of MPHL. The amount hrt of androgens present does not need to be greater than normal for MPHL to occur. If androgens are present in and normal amounts and the gene for hair loss is present, male pattern hair loss will occur. Axillary (under arm) and pubic hair are dependent on testosterone for growth. Beard growth and male pattern hair loss are dependent on dihydrotestosterone (DHT). Testosterone is converted to DHT by the enzyme, 5a -reductase. Finasteride (Propecia) acts by blocking this enzyme and decreasing the amount of DHT. Receptors exist on cells that bind androgens. These receptors have the greatest hair and loss affinity for DHT followed hrt by testosterone, estrogen, and progesterone. After binding to the receptor, DHT goes into the cell and interacts with the nucleus and and hair and loss of the cell altering the hrt production of protein by the DNA in the nucleus of the cell. Ultimately growth of the hair follicle ceases.
The hair growth cycle (see "The Normal Hair Growth and Cycle") is affected in that the percentage of hairs in the growth hair phase loss (anagen) and the duration of the growth hrt phase diminish and resulting in shorter hairs. More hairs are in the resting state (telogen) and these hairs are much more subject to loss with the daily trauma of combing and washing. The hair shafts in MPHL become progressively miniaturized, smaller in diameter and length, hair with time. In men with MPHL all the hairs in an affected area may eventually (but not necessarily) become involved loss in the process and may with time cover the region with fine (vellus) hair. Pigment (color) production is also hrt terminated and with miniaturization so the fine hair becomes lighter hair in color. The lighter color, miniaturized hairs cause the area to first appear thin. Involved areas in men can completely lose all follicles over time. MPHL is an inherited condition and the gene can be inherited from either loss the mother or father’s side. There is a common myth that inheritance is only from the mother’s side. This is not true.
Androgens (testosterone, dihydrotestosterone) are the most important control factors of human hair growth. Androgens must be present hrt for the growth of beard, and axillary (underarm), and pubic hair. Growth of scalp hair is NOT androgen-dependent but androgens are necessary hair for the development of male and female pattern hair loss.MALE PATTERN HAIR LOSS (Androgenetic Alopecia)It is estimated that 35 million men in the United States are affected by androgenetic alopecia. "Andro" refers to the androgens loss (testosterone, dihydrotestosterone) necessary to produce male-pattern hair loss (MPHL). "Genetic" refers to the inherited gene necessary for MPHL to occur. hrt In men and who develop MPHL the hair loss may begin any time after puberty when blood levels of androgens rise. The first change is usually recession in the temporal areas, which is seen in 96 percent of mature Caucasian males, including those hair men not destined to progress to further hair loss. Hamilton and later Norwood have classified the patterns of MPHL (See Norwood-Hamilton Scale). Although the density of hair in a given pattern loss of loss tends to diminish with age, there is no way to predict what pattern of hair loss a young man with early MPHL will hrt eventually assume. and In general, those who begin losing hair in the second decade are those in whom the hair loss hair will be the most severe. In some men, initial male-pattern hair loss may be delayed until loss the late third to fourth decade. It is generally hrt recognized and that men in their hair 20’s have a 20 percent incidence of MPHL, in their 30’s a 30 percent incidence of MPHL, in their 40’s a 40 percent incidence of MPLH, etc. Using these loss numbers one can see that a male in his 90’s has a 90 percent chance of having some degree of MPHL.
Come here to find hair loss treatments. A University developed treatment to help reverse hair loss.
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