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Hamilton first noted that androgens (testosterone, dihydrotestosterone) are necessary for the development of MPHL. The amount of androgens present does not need to be greater than normal for MPHL to occur. If androgens are present in normal amounts and the gene for hair loss is present, male pattern hair loss will occur. Axillary (under arm) and pubic hair are dependent on testosterone for growth. Beard growth and male pattern hair loss are dependent on dihydrotestosterone hairloss and crestor (DHT). Testosterone is converted to DHT by the enzyme, 5a -reductase. Finasteride (Propecia) acts by blocking this enzyme and decreasing the amount of DHT. Receptors exist on cells that bind androgens. These receptors have the greatest affinity for DHT followed by testosterone, estrogen, hairloss and progesterone. After binding to the receptor, DHT goes into the cell and interacts with the nucleus of the cell altering the production of protein by the DNA in the nucleus of the cell. Ultimately growth of the hair follicle ceases.
Androgens (testosterone, crestor dihydrotestosterone) are the most important control factors of human hair growth. Androgens must be present for the growth of beard, axillary (underarm), and pubic hair. Growth of scalp hair is NOT androgen-dependent but androgens are hairloss necessary for the development of male and female pattern hair loss.MALE PATTERN HAIR LOSS (Androgenetic Alopecia)It is estimated that 35 million crestor men in the United States are affected by androgenetic alopecia. "Andro" refers to the androgens (testosterone, dihydrotestosterone) necessary to produce male-pattern hair loss (MPHL). "Genetic" refers to the inherited gene necessary for MPHL to occur. In men who develop MPHL the hair loss may begin hairloss any time after puberty when blood crestor levels of androgens rise. The first change is usually recession in the temporal areas, which is seen in 96 percent of mature Caucasian males, including those men not hairloss destined to progress to further hair loss. Hamilton and later Norwood have classified the patterns of MPHL (See Norwood-Hamilton crestor Scale). Although the density of hair in a given pattern of loss tends to diminish with age, hairloss there is no way to predict what pattern of hair loss a young man with early MPHL will eventually assume. In general, those who crestor begin losing hair in the second decade are those in whom the hair loss hairloss and crestor will be the most severe. In some men, initial hairloss male-pattern hair loss may be delayed until the late third to fourth decade. It is generally recognized that men in their 20’s have a 20 percent incidence of MPHL, in their 30’s a 30 percent incidence of MPHL, in their 40’s a 40 percent crestor incidence of MPLH, etc. Using these numbers one can see that a male in his 90’s has a 90 percent chance of having some degree of MPHL.
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