Estrogen and hair loss

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Androgens (testosterone, dihydrotestosterone) Estrogen are and and hair the most important loss control factors of human hair growth. Androgens must be present for the growth of beard, axillary Estrogen (underarm), and pubic hair. Growth and of scalp hair is NOT androgen-dependent but androgens are hair necessary for the development of loss male and Estrogen female pattern hair loss.MALE PATTERN HAIR LOSS (Androgenetic and and hair Alopecia)It is estimated that 35 million men in the United States are affected by androgenetic alopecia. "Andro" refers to the androgens (testosterone, dihydrotestosterone) necessary loss and Estrogen to produce male-pattern hair loss (MPHL). "Genetic" and and hair refers to the inherited gene necessary for MPHL to occur. In men who develop MPHL the loss hair Estrogen loss and may begin any time after puberty hair when blood levels of androgens rise. The first change is usually recession in the temporal areas, which is seen in 96 percent of mature Caucasian males, including those men not destined to progress to further hair loss. Hamilton and later Norwood have classified the patterns of MPHL (See Norwood-Hamilton Scale). Although the density of hair in a given pattern of loss tends loss to diminish with Estrogen age, there is no way to predict what pattern and of hair loss a young man with early MPHL will eventually assume. In general, those who begin hair losing hair in the second decade are those in whom the hair loss will be the most severe. In some men, initial male-pattern hair loss may be delayed until loss and Estrogen the late third to fourth decade. It is generally recognized that men in their 20’s have a 20 percent incidence of MPHL, in their 30’s a 30 percent incidence of MPHL, in their 40’s and a 40 percent incidence of MPLH, hair etc. Using these numbers one can loss see that a male in his 90’s has a 90 percent chance of having some degree of MPHL.

Hamilton first noted that androgens (testosterone, dihydrotestosterone) are necessary for the development of MPHL. The amount of androgens present does not need to Estrogen be greater than normal for MPHL to occur. If androgens are present and in normal amounts and the gene for hair loss hair is present, male pattern hair loss will occur. Axillary (under arm) and pubic loss hair are dependent on testosterone for growth. Beard growth and male pattern hair loss are dependent on dihydrotestosterone (DHT). Testosterone is converted to DHT by the enzyme, 5a -reductase. Estrogen Finasteride (Propecia) and acts by blocking this enzyme and hair decreasing the amount loss and Estrogen of and DHT. Receptors exist on cells that bind androgens. These receptors have the greatest affinity for DHT followed by testosterone, estrogen, and progesterone. After binding to the receptor, DHT goes into the hair cell and interacts with the nucleus of the cell altering the production of protein by the DNA in the nucleus of the cell. Ultimately growth of the hair follicle ceases loss.

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Estrogen and hair loss

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