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Hamilton first noted that androgens (testosterone, dihydrotestosterone) are necessary hairloss for the development of MPHL. The amount of androgens present does not need talk to be greater than normal for MPHL to occur. If androgens are present in normal amounts and the gene for hair loss is present, hairloss male pattern hair loss will occur. Axillary (under arm) and pubic hair are dependent on testosterone for growth. Beard growth and male pattern hair loss are dependent on dihydrotestosterone (DHT). Testosterone is converted to DHT by the enzyme, 5a -reductase. Finasteride (Propecia) acts by blocking this enzyme and decreasing the amount of DHT. Receptors exist on cells that bind androgens. These receptors have the greatest affinity for DHT followed by testosterone, estrogen, and progesterone. After binding to the receptor, DHT goes into the cell and interacts with the nucleus of the cell altering the production of protein by the DNA in the nucleus of the cell. Ultimately talk growth of the hair follicle ceases.
THE hairloss NORMAL HAIR GROWTH CYCLEIt is important to understand the normal hair growth cycle to understand why hair loss occurs. talk The hair follicle is an anatomical structure which hairloss evolved to produce and extrude (push out) a hair shaft. Hair is made up of proteins called keratins. Human hair grows in a continuous cyclic pattern of growth and rest known as the "hair growth cycle". Three phases of the cycle exist: Anagen= growth talk phase; Catagen=degradation phase; Telogen= resting phase. Periods of growth (anagen) between two and eight years are followed by a brief period, two to four weeks, in which the follicle is almost totally degraded (catagen). The resting phase (telogen) hairloss then begins and lasts two to four months. Shedding of the hair occurs only after the next growth cycle (anagen) begins and a new hair shaft begins to emerge. On average 50-100 telogen hairs are shed every day. This is normal hair loss and accounts talk for the hair loss seen every day in the shower and with hair combing. hairloss These hairs will regrow. Not more talk than 10 percent hairloss of the follicles are in the resting phase (telogen) at any time. A variety of factors can affect the hair growth cycle and cause talk temporary hairloss or permanent hair loss (alopecia) including medication, radiation, chemotherapy, exposure to chemicals, hormonal and nutritional factors, thyroid disease, generalized or local skin talk disease, and stress.
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